Generic Name: ado-trastuzumab emtansine (AY doe tras TOOZ ue mab em TAN seen)Brand Name: Kadcyla, Medically reviewed by Drugs.com on Mar 17, 2020 – Written by Cerner Multum. It is important not to become pregnant or father a child while you're having treatment and for a few months afterwards. Symptoms of a blood clot include: If you have any of these symptoms, contact a doctor straight away. We report a phase II trial of T-DM1 monotherapy in relapsed NSCLC with documented HER2 positivity (an …
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• breast cancer that has spread or come back within 6 months of finishing treatment (advanced breast cancer) [35] Patients were required to have had neoadjuvant taxane and trastuzumab-based therapy with residual invasive tumor in the breast and/or axillary lymph nodes. Because the monoclonal antibody targets HER2, and HER2 is only over-expressed in cancer cells, the conjugate delivers the cytotoxic agent DM1 specifically to tumor cells.
Ado-trastuzumab emtansine is usually given after other treatments have failed.
If your white blood cell count is low, your doctor may reduce or delay your treatment for a short time. Clipboard, Search History, and several other advanced features are temporarily unavailable. These are called HER2 positive cancers. Ado-trastuzumab emtansine may also be used for purposes not listed in this medication guide.
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If the number of white blood cells is low, you are more likely to get an infection. [12], In the United States, ado-trastuzumab emtansine was approved specifically for treatment of HER2-positive metastatic breast cancer (mBC) in patients who have been treated previously with trastuzumab and a taxane (paclitaxel or docetaxel), and who have already been treated for mBC or developed tumor recurrence within six months of adjuvant therapy. This includes: Some people may need a drip to give them extra platelets.
If you get a high temperature, let your health care team know straight away. T-DM1 had a limited efficacy for HER2-positive NSCLC in our cohort.
This page was last edited on 20 October 2020, at 01:35.
This can make you more likely to get a mouth infection. You have regular blood tests to check for any changes in the way your liver is working. VAT no: 668265007. If you think you need dental treatment, talk to your cancer doctor or nurse. Contact the hospital straight away on the 24-hour contact number you have if: It is important to follow any specific advice your cancer treatment team gives you. Always tell your cancer doctor about any drugs you are taking or planning to take, such as: Tell other doctors, pharmacists or dentists who prescribe or give you medicines that you are having this cancer treatment. Search our clinical trials database for all cancer trials and studies recruiting in the UK, Questions about cancer?
You have trastuzumab emtansine as a drip into your bloodstream (intravenously).
2020 May;12(5):2896-2909. doi: 10.21037/jtd.2019.08.31.
signs of tumor cell breakdown--confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth. You might be breathless and look pale due to a drop in red blood cells. Talk to your nurse or doctor if you have this. Here are some tips that may help: If you have constipation, contact the hospital for advice. Published by Elsevier Inc. All rights reserved. A chemotherapy nurse will give it to you. The symptoms usually improve slowly after treatment finishes, but for some people they may never go away. It is used: As adjuvant therapy in patients with early-stage breast cancer. Your nurse will tell you when your treatment is likely to be ready. Trastuzumab emtansine can be given through: The nurse will give you trastuzumab emtansine as a drip into the vein (intravenous infusion).
Each molecule of trastuzumab emtansine consists of a single trastuzumab molecule with several molecules of DM1, a cytotoxic maytansinoid, attached. They could happen during treatment, or some months after treatment has finished. Copyright © 2017 International Association for the Study of Lung Cancer. If this isn't possible, wash your hands well after changing their nappy. After the 21 days are complete, you start your second cycle of treatment.
Tell your treatment team if you have this. You might feel very tired and as though you lack energy.
[13], In 2013, ado-trastuzumab emtansine was approved in the UK,[33] and the EU.
This is called anaemia. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. If you feel unwell or need advice, you can call them at any time of the day or night. We cannot list every side effect for this treatment.
You can visit the electronic Medicines Compendium (eMC) for more detailed information.
Your doctor can give you drugs to help control some side effects.
You have treatment through a thin short tube (a cannula) that goes into a vein in your arm each time you have treatment.
Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Trastuzumab emtansine (T-DM1), an anti-erb-b2 receptor tyrosine kinase 2 (HER2) antibody-drug conjugate, has been shown to significantly improve survival in HER2-positive breast cancer. | Use effective birth control, and tell your doctor if you become pregnant during treatment.
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